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. 2010 Sep 3;19(22):4399–4408. doi: 10.1093/hmg/ddq363

Figure 2.

Figure 2.

Increased cell body pathology in brains of KLC1 reduction combined with tau P301L. (A and C) Staining of phosphorylated tau using CP13 antibody. Neuronal cell bodies with abnormal p-tau accumulation are shown for dentate gyrus (A) and CA1 (C) region of the hippocampus in 3-, 6-, 9- and 12-month-old tauP301L;KLC1+/+ and tauP301L;KLC1+/− mice. (B and D) Stereological quantification of neuron numbers showing p-tau cell body accumulation in dentate (B) and CA1 (D) hippocampus for tauP301L;KLC1+/+ (black) and tauP301L;KLC1+/− (27). Distribution of the average number is plotted. Boxes and bars correspond to SEM and STDEV, respectively. Mann–Whitney, non-parametric test; n = 4, *P < 0.05.