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. 2010 Jul 22;299(4):G980–G989. doi: 10.1152/ajpgi.00080.2010

Fig. 1.

Fig. 1.

Effects of various cytokines, including interleukin (IL)-6 on apolipoprotein B (apoB) in primary rat hepatocytes (RH). A: RH were incubated overnight (16 h) in Waymouth's medium containing 2 nM tumor necrosis factor (TNF)-α (n = 3), 2 nM IL-1β (n = 6), 1 nM transforming growth factor (TGF)-β1 (n = 3), or 0.5 nM IL-6 (n = 6). Afterward, apoB accumulation in the medium was determined by RIA. Results are the average apoB concentration (ng/mg cell protein) ± SE for 3–5 replicate dishes/condition from n independent rat liver experiments. *P < 0.001 vs. basal medium. B: corresponding changes in cellular apoB levels as determined by RIA. C and D: dose-dependent effects of IL-6 on accumulation of apoB in medium and cellular apoB content, respectively. Results are the average apoB concentration of 5 plates/condition ± SD from one study. *Significant difference from basal conditions at a probability level of at least P < 0.05.