Table 2.
Group | Caloric Intake, kcal·day−1·mouse−1 | Weight, g | Glucose, mg/dl | Cholesterol, mg/dl | TG, mg/dl | AST, U/l | ALT, U/l | Insulin, ng/ml | Leptin, ng/ml | Adiponectin, μg/ml | HOMA-IR |
---|---|---|---|---|---|---|---|---|---|---|---|
Control | 12.28 ± 1.54 | 26.7 ± 0.3 | 137 ± 15 | 69.6 ± 6.2 | 51.8 ± 3.1 | 37.8 ± 2.4 | 8.8 ± 1.8 | 0.087 ± 0.011 | 0.86 ± 0.17 | 9.94 ± 0.733 | 0.28 ± 0.04 |
EtOH | |||||||||||
10% | 12.83 ± 0.63 | 26.4 ± 0.5 | 112 ± 13 | 83.1 ± 5.7 | 67.4 ± 9.6 | 43.0 ± 8.4 | 14.6 ± 3.9 | 0.11 ± 0.020 | 2.42 ± 0.19f | 9.77 ± 1.217 | 0.36 ± 0.07 |
14% | 13.44 ± 0.65 | 24.3 ± 0.5b | 143 ± 9 | 68.6 ± 4.2 | 64.7 ± 6.0 | 48.8 ± 10.5 | 12.5 ± 2.4 | 0.13 ± 0.010c | 1.84 ± 0.38b | 13.39 ± 0.735b | 0.45 ± 0.05d |
18% | 15.24 ± 1.36 | 25.5 ± 0.5 | 108 ± 7 | 64.0 ± 5.2 | 86.0 ± 9.4b | 46.6 ± 10.9 | 10.0 ± 2.0 | 0.17 ± 0.010f | 3.66 ± 0.98c | 13.06 ± 0.976c | 0.56 ± 0.05f |
HFD | 18.53 ± 2.73a | 36.6 ± 1.2d | 220 ± 10d | 104 ± 7.3e | 77 ± 9.2c | 41.4 ± 4.8 | 7.8 ± 1.2 | 0.13 ± 0.02f | 49.6 ± 11.3d | 12.06 ± 0.863a | 0.50 ± 0.08c |
db/db | 18.11 ± 1.04c | 51.4 ± 0.8d | 120 ± 10 | 182 ± 6d | 59 ± 16 | 57.2 ± 7.4b | 102 ± 22d | 2.41 ± 0.69d | 1145 ± 486b | 8.32 ± 0.930 | 7.35 ± 2.19e |
ob/ob | 20.57 ± 1.54d | 61.8 ± 0.6d | 155 ± 9 | 194 ± 7d | 83 ± 8d | 54.0 ± 4.4e | 99 ± 7d | 1.48 ± 0.46b | 0.44 ± 0.09 | 11.77 ± 0.875 | 4.95 ± 1.57d |
Values are means ± SE. EtOH, ethanol; TG, triglyceride; HFD, high-fat diet; AST, aspartate aminotransferase; ALT, alanine aminotransferase; HOMA-IR, homeostasis model assessment of insulin resistance.
0.1 > P > 0.05,
P < 0.05,
P < 0.025,
P < 0.01,
P < 0.005,
P < 0.001 vs. control.