Fig. 6.
Effect of PKC inhibition on 20-HETE-induced increases in L-type Ca2+ channel activity. A: representative original recording of ICa,L in isolated cardiac myocytes treated with Veh Con or GF (1 μM) before and after the addition of 20-HETE (100 nM). B: bar graph summarizing the action of 20-HETE (100 nM) on ICa,L of isolated cardiomyocytes pretreated with GF (1 μM) or Veh Con. Data are means ± SE of ICa,L density in isolated cardiomyocytes; n = 9 and 11. *P < 0.01 compared with Con; #P < 0.05 vs. treatment with Veh plus 20-HETE.