Fig. 13.

ACh-induced dilation in untreated arteries and arteries treated with a combination of the Hsp90 antagonist GA and the prostanoid inhibitor indomethacin from piglets raised in normoxia for 3 days (A; n = 13 untreated arteries and 6 treated arteries), hypoxia for 3 days (B; n = 12 untreated arteries and 14 treated arteries), normoxia for 10 days (C; n = 19 untreated arteries and 20 treated arteries), and hypoxia for 10 days (D; n = 14 untreated arteries and 14 treated arteries). Data are expressed as percent dilation of contraction elicited by either U-46619 or endothelin. All values are means ± SE. *Significantly different from the concentration-response curve in untreated arteries (P < 0.05 by the linear mixed effects model).