Table 6.

Association of melanocortin-1 receptor (MC1R) variants with median ages at diagnosis of melanoma in case patients carrying cyclin-dependent kinase inhibitor 2A (CDKN2A) mutations^*

MC1R variant	Europe			North America			Australia			All continents
	No. of melanoma patients	Median age at diagnosis	P†	No. of melanoma patients	Median age at diagnosis	P†	No. of melanoma patients	Median age at diagnosis	P†	No. of melanoma patients	Median age at diagnosis	P†
Individual MC1R variants
V60L	108			50			32			190
0		39			31.5			33			36.5
≥1		37	.31		34.5	.57		37	.68		36	.61
V92M	91			28			24			143
0		39			31.5			33			36.5
≥1		39	.17		30.5	.50		33	.43		34	.08
R151C	115			35			57			207
0		39			31.5			33			36.5
≥1		35	.03		29	.43		34	.92		34	.05
R160W	94			35			23			152
0		39			31.5			33			36.5
≥1		34	.05		31	.73		33	.90		35	.06
Any MC1R variant	268			115			87			470
0		39			31.5			33			36.5
≥1		35	.11		31	.93		34	.94		35	.13
No. of MC1R variants	268			115			87			470
0		39			31.5			33			36.5
1		36			34			35			35
≥2		35	.10		29.5	.14		33	.85		34	.06
Types of MC1R variants	268			115			87			470
0		39			31.5			33			36.5
1 NRHC‡		38			34.5			36			37
1 RHC§		34			31			34			34
≥ 2 NRHC		40			31			31.5			36
1 RHC, 1 NRHC		35			29			34			33.5
≥2 RHC		35	.02		27	.07		33.5	.92		34	.008

^*The median ages at diagnosis of melanoma were estimated in melanoma patients carrying CDKN2A mutations from each continent and from all three continents for each category of MC1R variables (individual MC1R variants, any MC1R variant, number of MC1R variants, types of MC1R variants). NRHC = nonred hair color; RHC = red hair color.

^†P values for the two-sided Jonckeere–Terpstra test used to test for a change in age at diagnosis of melanoma with presence of individual MC1R variants, presence of any variant or as the number and number and types of MC1R variants increased.

^‡Nonsynonymous MC1R variants that were not RHC variants.

^§Red hair color variants included R151C, R160W, D294H, and D84E.