Figure 1. The clinical course of EAE was attenuated by berberine treatment.

Daily clinical score (A), maximal score (B) and cumulative score (C) of the PBS- and berberine-treated EAE mice. EAE was induced in female C57 BL/6 mice with MOG 35-55 and treatment with berberine was performed as described under materials and methods. Each group had seven animals. Drug treatments were started from the day of disease onset. Values represent the mean±S.E.M., **P<0.01 vs. PBS-treated EAE mice.