Figure 4. The effect of berberine on brain BBB permeability in EAE mice.

The integrity of BBB was detected by quantitative measurement for EB content at day 20 p.i. in six animals per group. EB is expressed as micrograms per gram of brain tissue against a standard curve. Values represent the mean±S.E.M., ** P<0.01 vs. control mice, ^##P<0.01 vs. PBS-treated EAE mice.