Fig. 2.
Maternal diabetes reduced the excitability of PCMNs in response to current injections. A, 1 and 2: representative PCMN spikes in response to current injections at 40 and 80 pA in a control animal. B, 1 and 2: representative PCMN spikes in response to current injections at 40 and 80 pA in a neonatal mouse with diabetic mother (NMDM). C: mean spike frequency was markedly reduced in NMDM compared with that in control animal (†P < 0.05). D: mean spike frequencies in response to current injections (40–140 pA) were comparable in NMDM (with nontransgenic and transgenic neonates from their own diabetic mothers), nontransgenic neonates fed by surrogate nondiabetic mothers, and transgenic neonates fed by surrogate nondiabetic mothers.