Fig. 5.
Maternal diabetes increased the transient outward current in PCMNs. A: control. The outward currents were evoked by the voltage steps from −70 to +40 mV for 250 ms in 10 mV steps every 5 s to show the transient currents. B: NMDM. The outward currents were evoked by voltage steps using the same protocol as in A. C: control. Outward currents evoked by voltage steps from −70 to +30 mV for 800 ms in 10 mV steps every 5 s to show the persistent currents. D: NMDM. Outward currents evoked by voltage steps using the same protocol as in C. E: the transient outward currents in NMDM significantly increased compared with control (as shown in inset E′, †P < 0.05), but the transient outward currents were similar in NMDM, nontransgenic neonates/surrogate mothers and transgenic neonates/surrogate mothers (as shown in E. P > 0.05). F: the persistent outward currents were not significantly different among the four different groups. Vm: membrane potential. The symbols for different mouse groups are shown at the bottom right of the figure.