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. Author manuscript; available in PMC: 2011 Feb 1.
Published in final edited form as: Bioorg Med Chem Lett. 2009 Dec 21;20(3):966–970. doi: 10.1016/j.bmcl.2009.12.051

Scheme 2.

Scheme 2

Preparation of bis-3,5-difluoro-4-hydroxybenzenesulfonamide 13: (a) K2CO3, CH3I, DMF, 50 °C, 65%; (b) chlorosulfonic acid, CH2Cl2, reflux, 2 hr, 85%; (c) N,N′-diethylethylenediamine, Et3N, EtOAc, 40%; (d) 1M BBr3 in CH2Cl2, CH2Cl2, 0 °C to rt, 67%.