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. Author manuscript; available in PMC: 2011 Nov 1.
Published in final edited form as: Schizophr Res. 2010 Sep 15;123(2-3):93–104. doi: 10.1016/j.schres.2010.08.027

Table 3.

Somatosensory Studies

Study: Method: Design: Insula Involvement:
Peyron et al. (2000) Meta-analysis of
imaging studies		 Articles about pain processing published on or
before 1999		 Involvement of insula in 90% of studies
Apkarian et al. (2005) Meta-analysis of
imaging studies		 Articales about pain processing published on or
before 2004		 Involvement of insula in 94% of studies
Farrell et al. (2005) Meta-analysis using
activation likelihood
estimations (ALE)		 Noxious heat applied to either upper limb
 Increses in posterior insula contralateral to site of
stimulation along with anterior insula response bilaterally
Berthier (1988) Lesion study,
qualitative		 Asymbolia for pain Associated with Involvement of insula, particular posterior
subdivision