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. Author manuscript; available in PMC: 2011 Nov 1.
Published in final edited form as: Expert Opin Drug Metab Toxicol. 2010 Sep 28;6(11):1333–1346. doi: 10.1517/17425255.2010.522177

Figure 4.

Figure 4

Cell viability (as determined by LDH leakage) and cellular GSH levels of freshly isolated male (A, C) and female (B, D) hepatocytes (n=3–4) incubated with medium alone or medium spiked with 3-MTP (0.3 mM) for 0–5 h at 37°C. The symbol * indicates values that were significantly lower than cells incubated with medium alone (*p<0.05, **p<0.01). Adapted from Dever JT, Elfarra AA. L-methionine toxicity in freshly isolated mouse hepatocytes is gender-dependent and mediated in part by transamination. J Pharmacol Exp Ther 2008;326:809–817 with permission from the American Society for Pharmacology and Experimental Therapeutics.