Table 3.
Oxidation rate constant of gp120-OD8 Asp digests
| Peptide sequence [residue range] | Modified residues and its mass shift (Da) | SASA (Å2) in homology | Rate s-1 |
|---|---|---|---|
| RSTQLLLNGSLAEEEIIIRSE [1-21] | L6 (+16/14) L11(+16)R19 (+16) | R19(104.64) | 8.5 ± 1.2 |
| NNTRKSIHIGPGQAFYATGEIIG[47-69] (V3loop) | K51 I55 F61 I67 H54 (+16) | K51(134.9) I55(129.9) F61(85.8) H54(81.7) I67(137.8) | 7.4± 1.7 |
| NISRTKW [77:83] | W83 (+32) | W83(5.1) | 7.0 ± 1.4 |
| NKTIIFKPSSGG [100:111] | K101 F104 K106 (+16) | K101(56.7) F104(33.3) K106(87.0) | 1.1 ± 0.06 |
| NSTWMF [136:141] (+1) | W139 (+32 / 4) M140 F141 (+16) | W139(28.3) M140(76.2) F141(135.9) | 29 ± 8.4 |
| NTSGLFNSTWMF [130:141] | W139(+32) M140(+16) F141(+16) | W139 (28.29) M140(76.2) F141 (135.9) | 37± 7.3 |
| NGTYMF[142:147] (+1) | F141 M146 (+ 16) | F141(135.9) M146(198.0) | 23± 3.4 |
| NSTWMFNGTYMF [136:147] (+2) | W 139 (+32) M140(+32) | W139(28.29) M140(76.2) | 36 ± 4.0 |
| NGTYMFNGTR [142:151] (+2) | M146 F147 R151(+16) | M146(198.0) F147(144.0) R151(190.6) | 31 ± 1.7 |
| NITGLLLTR [191:199] | L196 or L197 (+16) | L196(0) L197(0) | 0.36 ± 0.13 |
| DGGNNSNKNKTETFRPGGGD [200:218] | K207/K209 (+16) | K207(136.6) K209(100.2) | 1.5 ± 0.05 |
| NKTETFRPGGGDMR [208:221] | P215 M220 R221(+16) F213(-30) | P215(0) M220(24.5) R221(156.0) F213(0) | 87± 11 |