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. Author manuscript; available in PMC: 2011 Nov 15.
Published in final edited form as: Dev Biol. 2010 Sep 21;347(2):301–314. doi: 10.1016/j.ydbio.2010.08.027

Figure 8.

Figure 8

Expression of FoxM1-ΔN transgene in the adult lung causes hyperplasia of Clara cells. Histological staining and IHC of lungs isolated from epFoxM1 and WT mice after Dox treatment for 3 months. (A-B) H&E staining displayed focal epithelial hyperplasia in epFoxM1 lungs (arrows). IHC with antibodies against FoxM1-ΔN (C-D), Ki-67 (E-F) and CCSP (G-H) showed expression of these proteins in hyperplastic airway regions of Dox-treated epFoxM1 mice (arrows). (I-P) Rare lung adenomas (Ad) were detected in epFoxM1 lungs. These tumors were positive for Ki-67 (N) and pH3 (P), but negative for FoxM1-ΔN transgene (L).