Table 3.
List of 6 growth-defective mutants of F. tularensis and the co-localization of the FCP with LAMP-1 in hMDMs
Strain Name | Locus Tag | Gene | %Co-localization with Lamp1 | Log reduction in Growth relative to WT |
---|---|---|---|---|
Control | ||||
Sua5/YciO/YrdC family protein | 17 | 0 | ||
Intracellular growth locus C | IglC | 88 | 6 | |
Selected Mutants | ||||
tnfn1_pw060328p05q136 | FTN_0384 | 20 | 2 | |
tnfn1_pw060323p07q141 | FTN_0788 | 75 | 4 | |
tnfn1_pw060323p01q177 | FTN_0799 | emrE | 26 | 3 |
tnfn1_pw060510p01q158 | FTN_0988 | prmA | 84 | 4 |
tnfn1_pw060420p02q179 | FTN_1263 | comL | 78 | 5 |
tnfn1_pw060323p01q113 | FTN_1343 | 72 | 2 |