Figure 4. Maintenance of ESC pluripotency on fibronectin microarrays in coculture with MEFs.
A. ESCs attached to the fibronectin microarray after 1 day. B. ESCs remained viable on the microarray after 2 days, based on robust calcein uptake (green). C. Phase-contrast images depict coculture of ESCs and MEFs on ECM microarray after 1 day. D. Alkaline phosphatase staining of ESCs in coculture with MEFs after 2 days indicates pluripotent phenotype. Scale bar: 500µm (A,C); 200µm (B); 300µm (D).