Table 3.
Intention to treat analysis. Values are numbers (percentages) unless stated otherwise
Control (high flow oxygen) | Active (titrated oxygen) | Treatment effect | P value | |
---|---|---|---|---|
Mortality | ||||
All patients | 21/226 (9) | 7/179 (4) | 0.42 (0.20 to 0.89)* | 0.02 |
Confirmed COPD | 11/117 (9) | 2/97 (2) | 0.22 (0.05 to 0.91)* | 0.04 |
Incidence of ventilation | ||||
All patients | 19/213 (9) | 13/166 (8) | 0.88 (0.45 to 1.72)* | 0.70 |
Non-invasive ventilation | 7 | 8 | ||
Invasive ventilation | 12 | 5 | ||
Confirmed COPD | 15/105 (14) | 8/84 (10) | 0.67 (0.29 to 1.54)* | 0.34 |
Non-invasive ventilation | 6 | 5 | ||
Invasive ventilation | 9 | 3 | ||
Length of hospital stay (mean (SD) days) | ||||
All patients | 5.9 (5.6) (n=226) | 5.5 (5.9) (n=179) | −0.45 (0.57)† | 0.19 |
Confirmed COPD | 6.3 (5.8) (n=117) | 5.4 (4.1) (n=97) | −0.88 (0.70)† | 0.37 |
Arterial blood gases (<30 min) (confirmed COPD patients) | ||||
Mean (SD) pH | 7.29 (0.14) (n=19) | 7.35 (0.16) (n=19) | 0.06 (0.05)† | 0.11 |
Mean (SD) carbon dioxide (mm Hg) | 77.8 (49.2) (n=20) | 54.7 (31.1) (n=20) | −23.1 (13.0)† | 0.06 |
Mean (SD) bicarbonate (mmol/l) | 32.3 (10.1) (n=19) | 26.8 (6.5) (n=19) | −5.5 (2.76)† | 0.07 |
Mean (SD) oxygen (mm Hg) (arterial only) | 98.4 (46.1) (n=14) | 79.3 (24.9) (n=9) | −19.1 (16.8)† | 0.34 |
COPD=chronic obstructive pulmonary disease.
*Relative risk (95% CI).
†Mean difference (SE).