Table 4.
Treatment per protocol. Values are numbers (percentages) unless stated otherwise
| Control (high flow oxygen) | Active (titrated oxygen) | Treatment effect | P value | |
|---|---|---|---|---|
| Mortality | ||||
| All patients | 16/177 (9) | 3/66 (5) | 0.50 (0.16 to 1.54)* | 0.23 |
| Confirmed COPD | 9/92 (10) | 1/43 (2) | 0.24 (0.04 to 1.57)* | 0.14 |
| Incidence of ventilation | ||||
| All patients | 19/167 (11) | 5/63 (8) | 0.70 (0.25 to 1.97)* | 0.50 |
| Non-invasive ventilation | 7 | 4 | ||
| Invasive ventilation | 12 | 1 | ||
| Confirmed COPD | 15/83 (18) | 3/40 (8) | 0.42 (0.14 to 1.20)* | 0.11 |
| Non-invasive ventilation | 6 | 2 | ||
| Invasive ventilation | 9 | 1 | ||
| Length of hospital stay (mean (SD) days) | ||||
| All patients | 5.9 (5.5) (n=177) | 6.0 (5.3) (n=66) | 0.09 (0.78)† | 0.87 |
| Confirmed COPD | 6.5 (6.0) (n=92) | 6.2 (4.6) (n=43) | −0.29 (1.04)† | 0.96 |
| Arterial blood gases (<30 min) (confirmed COPD patients) | ||||
| Mean (SD) pH | 7.29 (0.15) (n=18) | 7.41 (0.09) (n=10) | 0.12 (0.05)† | 0.01 |
| Mean (SD) carbon dioxide (mm Hg) | 76.5 (50.2) (n=19) | 42.9 (14.2) (n=10) | −33.6 (16.3)† | 0.02 |
| Mean (SD) bicarbonate (mmol/l) | 31.5 (9.9) (n=18) | 26.0 (4.2) (n=10) | −5.5 (3.30)† | 0.15 |
| Mean (SD) oxygen (mm Hg) (arterial only) | 98.4 (46.1) (n=14) | 81.5 (30.9) (n=6) | −16.9 (20.7)† | 0.46 |
COPD=chronic obstructive pulmonary disease.
*Relative risk (95% CI).
†Mean difference (SE).