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Effects of endogenous testosterone on Akt downstream signals: Bad, Bcl-2 and Bax. Higher levels of p-Bad (A), anti-apoptotic Bcl-2 mRNA (B) and protein (C) in female, castrated male and male+Flut hearts after I/R. D. Bax mRNA; E. Bax protein; F. The ratio of Bcl-2/Bax (mRNA and protein). N=4-9/group, Mean ± SEM, *p<0.05, **p<0.01, ***p<0.001 vs. Male.
