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. Author manuscript; available in PMC: 2011 Nov 15.

Published in final edited form as: Bioorg Med Chem Lett. 2010 Sep 19;20(22):6394–6399. doi: 10.1016/j.bmcl.2010.09.088

Table 3.

Near kinase selectivity panel of pyrazolopyrimidines and aminooxazoles.

IC₅₀ (µM)^a

No.	hAMPKα2	c-Src	EphA2	Flt1	Flt3	KDR	Lck	Mnk1	Rsk1
Compound	0.041	0.002	0.011	0.011	<0.001	0.004	0.016	0.011	0.21
C
4	0.27	0.050	0.25	0.21	0.001	0.056	0.30	0.13	2.1
5	0.061	0.061	0.26	0.47	<0.001	0.10	0.43	0.045	2.1
7	0.14	3.3	0.30	0.004	<0.001	0.010	0.094	0.027	0.22
8	0.22	0.021	0.84	0.040	0.001	0.058	0.44	0.164	1.1
11	1.1	0.096	0.74	0.002	0.001	0.001	0.02	0.95	0.56
21	2.8	3.2	>10	0.074	0.13	0.100	0.97	2.2	3.4
22	5.0	8.2	5.6	>10	0.12	>10	>10	1.10	>10

^a

as in Table 1.