Table 3.

Serum calcium and magnesium baseline values, changes from baseline values at Week 25 and number of visits > ULN and <LLN, as well as above and below K/DOQI range (for Ca) (FAS, N = 244)

Parameter	CaMg		Sevelamer-HCl		P-value
	N	(Mean ± SD)	N	(Mean ± SD)
Ionized calcium (mmol/L)
Baseline	113	1.071 ± 0.1608	112	1.076 ± 0.1306
Week 25	120	1.104 ± 0.1210	119	1.113 ± 0.1063
Change at Week 25	112	0.036 ± 0.1702	110	0.036 ± 0.1369
Treatment difference (LS-means) [confidence interval]	−0.0015 [−0.0294, 0.0264]				0.9173
Total serum calcium (mmol/L)
Baseline	122	2.148 ± 0.2288	122	2.185 ± 0.1820
Week 25	122	2.219 ± 0.1565	122	2.189 ± 0.1574
Change at Week 25	122	0.071 ± 0.1790	122	0.004 ± 0.1522
Treatment difference (LS-means) [confidence interval]	0.0477 [0.0162, 0.0793]				0.0032
No. of visits Ca > ULN (2.6 mmol/L)	122	0.11 ± 0.460	122	0.07 ± 0.563	0.2374
No. of visits Ca < LLN (2.2 mmol/L)	122	4.31 ± 3.695	122	4.55 ± 3.827	0.6839
No. of visits Ca > K/DOQI range (2.37 mmol/L)	122	1.81 ± 2.881	122	1.25 ± 2.412	0.1005
No. of visits Ca < K/DOQI range (2.10 mmol/L)	122	2.23 ± 2.911	122	2.38 ± 3.178	0.4809
Serum magnesium (mmol/L)
Baseline	122	0.993 ± 0.1544	122	0.996 ± 0.1613
Week 25	122	1.297 ± 0.2547	122	1.039 ± 0.1851
Change at Week 25	122	0.304 ± 0.2285	122	0.043 ± 0.1453
Treatment difference (LS-means) [confidence interval]	0.2597 [0.2137, 0.3056]				<0.0001
No. of visits Mg > ULN (1.05 mmol/L)	122	7.86 ± 2.514	122	4.10 ± 3.797	<0.0001
No. of visits Mg < LLN (0.65 mmol/L)	122	0.04 ± 0.237	122	0.04 ± 0.237	1.0000