Table 5.

Actual bicarbonate, base excess, LDL-cholesterol and potassium at baseline, changes from baseline and at Week 25 (FAS, N = 244)

Parameter	CaMg		Sevelamer-HCl		P-value
	N	(Mean ± SD)	N	(Mean ± SD)
Actual bicarbonate (mmol/L)
Baseline	106	21.086 ± 2.6587	102	21.588 ± 3.4209
Week 25	117	22.496 ± 3.3095	114	21.086 ± 4.0833
Change at Week 25	106	1.500 ± 3.1117	101	−0.823 ± 4.3323	<0.0001
Treatment difference (LS-means) [confidence interval]	1.8435 [0.9462, 2.7408]				<0.0001
Base excess
Baseline	110	−3.729 ± 2.9518	107	−3.133 ± 3.6341
Week 25	121	−2.340 ± 3.4567	118	−3.702 ± 4.2831
Change at Week 25	110	1.594 ± 3.2531	106	−0.853 ± 4.3851	<0.0001
Treatment difference (LS-means) [confidence interval]	1.9466 [1.0171, 2.8761]				<0.0001
LDL-cholesterol (mg/dL)
Baseline	122	112.71 ± 31.717	122	115.03 ± 30.346
Week 25	116	110.19 ± 30.060	105	87.17 ± 27.870
Change at Week 25	116	−2.85 ± 21.458	105	−28.09 ± 25.746
Treatment difference (LS-means) [confidence interval]	23.5287 [17.9405, 29.1169]				<0.0001
Potassium (mmol/L)
Baseline	122	5.50 ± 0.967	122	5.36 ± 0.732
Week 25	118	5.79 ± 0.793	112	5.39 ± 0.807
Change at Week 25	118	0.27 ± 0.968	112	0.03 ± 0.776
Treatment difference (LS-means) [confidence interval]	0.3192 [0.1250, 0.5134]				0.0014