Table 3.
Correlation between clinicopathological parameters and p53 and p21 over-expression in esophageal squamous cell carcinoma patients n (%)
| Number |
p53 over-expression |
p21 over-expression |
|||||
| Yes | No | P value | Yes | No | P value1 | ||
| Age (yr) | |||||||
| < 60 | 36 | 10 (27.8) | 26 (72.2) | NS | 14 (38.9) | 22 (61.1) | NS |
| ≥ 60 | 44 | 13 (29.5) | 31 (70.5) | 16 (36.4) | 28 (63.6) | ||
| Gender | |||||||
| Male | 45 | 15 (33.3) | 30 (66.7) | NS | 20 (44.4) | 25 (55.6) | NS |
| Female | 35 | 8 (22.9) | 27 (77.1) | 10 (28.6) | 25 (71.4) | ||
| Smoking | |||||||
| Ever-user | 28 | 13 (46.4) | 15 (53.6) | 0.01 | 14 (50) | 14 (50) | 0.09 |
| Never-user | 52 | 10 (19.2) | 42 (80.8) | 16 (30.8) | 36 (69.2) | ||
| Differentiation | |||||||
| Well | 46 | 12 (26.1) | 34 (73.9) | 20 (43.5) | 26 (56.5) | ||
| Moderate | 23 | 8 (34.8) | 15 (65.2) | 6 (26.1) | 17 (73.9) | NS | |
| Poor | 11 | 3 (27.3) | 8 (72.7) | NS | 4 (36.4) | 7 (63.6) | |
| Tumor site | |||||||
| Middle | 59 | 19 (32.2) | 40 (67.8) | NS | 26 (44.1) | 33 (55.9) | NS |
| Lower | 20 | 4 (20) | 16 (80) | 4 (20) | 16 (80) | ||
| Size of tumor (cm) | |||||||
| < 3 | 23 | 8 (34.8) | 15 (65.2) | 5 (21.7) | 18 (78.3) | 0.07 | |
| ≥ 3 | 53 | 15 (28.3) | 38 (71.7) | NS | 23 (43.4) | 30 (56.6) | |
| Operability | |||||||
| Operable | 45 | 12 (26.7) | 33 (73.3) | NS | 17 (37.8) | 28 (62.2) | NS |
| Inoperable | 35 | 11 (31.4) | 24 (68.6) | 13 (37.1) | 22 (62.9) | ||
1
Not statistically significant by χ2 test. NS: Not significant.