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Gene expression of endothelin-1 after bosentan treatment. MCT increased ET-1 gene expression compared with controls on day 5 (p<0.05), and bosentan blocked this increase (p<0.05). *p<0.05 vs. control group, †p<0.05 vs. MCT group. MCT: monocrotaline, ET-1: Endothelin-1.
