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. 2010 Oct 15;11(Suppl 7):S16. doi: 10.1186/1471-2105-11-S7-S16

Figure 4.

Figure 4

Structures of docked TSA with HDAC Class II Homo sapiens. Three Conformations of Structures of docked TSA with (A) HDAC4, (B) HDAC5, (C) HDAC6, (D) HDAC7, (E) HDAC9 and (F) HDAC10. A surface representation of catalytic domain of Homo sapiens Class II HDACs bound to TSA. The zinc ion is shown as gray sphere. TSA are shown as stick models colored as per docked type: red, blue, and yellow. Amino acids coordinating the zinc and forming the trihedrally coordinates are shown as sticks. Some catalytic domain of Homo sapiens Class II HDACs residues interacting with the docked TSA are shown as stick models. Except HDAC5-TSA complex, all of Homo sapiens class II HDACs-TSA complexes bind the catalytic zinc ion in a monodentate fashion.