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mRNA analysis of proinflammatory factors in colon tissue from WT and Pxr-null mice. Colon RNA was isolated from WT and Pxr-null mice treated with control (Cont), DSS, Rifax, and DSS/Rifax. Expression of mRNAs encoding iNOS, CCR2, TNFα, IFNα, ICAM-1, MCP-1, IL-10, IL-6, and IL-1β was determined by qPCR. Data were normalized to β-actin. Each bar represents the mean ± standard deviations. n ≥ 6. *, p < 0.05; **, p < 0.01; ***, p < 0.001.
