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Effect of STZ treatment on total, cholinergic, and purinergic EFS contraction in wild-type and M2 KO urinary bladders lacking urothelium. The total (a), cholinergic (b), and purinergic (c) components of EFS contraction were measured at 8 to 9 weeks after STZ treatment and after 20 to 24 weeks (d, e, f, respectively). Mean values ± S.E.M. from 3 to 10 experiments are shown. Significantly different from vehicle (*, P < 0.05, **, P < 0.001).
