TABLE 1.
Body weight percentage change and fasting blood glucose levels 8 to 24 weeks after STZ injection
The mean estimate ± S.E.M. are shown. The number or replicates is indicated in parentheses.
| % Body Weight Change |
Fasting Blood Glucose |
||||
|---|---|---|---|---|---|
| Wild Type | M2 KO | Wild Type | M2 KO | ||
| mg/dl | |||||
| 8 to 9 Weeks after treatment | |||||
| Vehicle | 18.0 ± 1.8 (19) | 13.5 ± 2.0 (18) | 112 ± 5 (19) | 113 ± 6 (18) | |
| STZ | −3.8 ± 2.8*** (18) | −0.2 ± 3.6* (17) | 426 ± 32*** (13) | 461 ± 32*** (14) | |
| 20 to 24 Weeks after treatment | |||||
| Vehicle | 38.9 ± 6.3 (8) | 41.7 ± 1.5 (7) | 139 ± 6.5 (8) | 144 ± 8.7 (7) | |
| STZ | 2.1 ± 5.7** (8) | 8.9 ± 4.2*** (4) | 492 ± 42*** (8) | 602 ± 92*** (4) | |
*
P < 0.05, significantly different from vehicle.
**
P < 0.001, significantly different from vehicle.
***
P < 0.0001, significantly different from vehicle.