TABLE 3.
Summary of pEC50 and Emax values after isoproterenol-mediated inhibition of EFS contraction
The parameters were estimated from the data in Figs. 6 and 7. Mean values ± S.E.M. are shown, and the number of replicates is indicated within parentheses.
| Denuded Bladder |
Intact Bladder |
|||||||
|---|---|---|---|---|---|---|---|---|
| pEC50 |
Emax (% Control) |
pEC50 |
Emax (% Control) |
|||||
| WT | M2 KO | WT | M2 KO | WT | M2 KO | WT | M2 KO | |
| 8 to 9 Weeks | ||||||||
| Vehicle | 7.41 ± 0.32 (6) | 7.58 ± 0.30 (3) | 87 ± 4.0 (6) | 71 ± 4.8 (3) | 7.26 ± 0.16 (6) | 7.89 ± 0.56 (3) | 84 ± 2.7 (6) | 43 ± 9.9 (3) |
| STZ | 7.49 ± 0.21 (4) | 7.83 ± 0.31 (5) | 89 ± 2.0 (4) | 59 ± 4.2 (5) | 7.35 ± 0.16 (4) | 7.74 ± 0.24 (5) | 80 ± 2.7 (4) | 60 ± 3.9 (5) |
| 20 to 24 Weeks | ||||||||
| Vehicle | 7.78 ± 0.32 (5) | 7.79 ± 0.15 (4) | 83 ± 2.9 (5) | 82 ± 1.6 (4) | 7.71 ± 0.19 (5) | 7.96 ± 0.46 (4) | 88 ± 1.9 (5) | 73 ± 4.5 (4) |
| STZ | 7.75 ± 0.25 (3) | 8.11 ± 0.28 (4) | 85 ± 3.4 (3) | 19 ± 4.1 (4) | 7.64 ± 0.13 (3) | 7.98 ± 1.3 (4) | 83 ± 2.1 (3) | 49 ± 15 (4) |