Fig. 3.

Eticlopride pretreatment (A), but not SCH23390 pretreatment (B), attenuates METH-induced loss of VMAT2 as assessed 24 h after METH treatment. Rats received four injections of METH (7.5 mg/kg s.c. per injection; 2-h intervals) or saline vehicle (1 ml/kg s.c. per injection; 2-h intervals) and were sacrificed 24 h later. Thirty minutes before each injection, rats were pretreated with eticlopride (A; 0.5 mg/kg i.p.), SCH23390 (B; 0.5 mg/kg i.p.), or saline vehicle (1 ml/kg i.p.). Columns represent the means and vertical lines indicate 1 S.E.M. determinations in six to nine rats. *, values different from saline-treated controls (p ≤ 0.05).