Fig. 2.
Top and middle, effects of the GABAB receptor-positive modulators CGP7930 (top) and rac-BHFF (middle), administered intraperitoneally, on loss of righting produced by baclofen (top and middle left) and GHB (top and middle right). Symbols represent mean ± S.E.M righting scores, totaled for each animal (n = 8 mice per dose) across the six different times after injection. Data obtained in the presence of 320 mg/kg CGP35348 are indicated by ▴. Bottom, Schild-like plot of dose ratios for baclofen and GHB, calculated from the ED50 values of the dose-response curves shown in the top and middle, as a function of the dose of the positive modulator.