Fig. 5.

In vivo effect of rLCAT on lipoprotein profile of LCAT-KO mice. rLCAT (2900 units) was injected intravenously into LCAT-KO mice (n = 5). Control group of LCAT-KO mice (n = 5) was injected with PBS. Pooled plasma at baseline (dotted line), 4 h (large dashed line) and 24 h (solid line) after rLCAT treatment was fractionated by FPLC and analyzed for cholesterol (A) and CE (B). C, LCAT activity was measured after intravenous rLCAT injection for the indicated times. Results are expressed as percentage of first time point (5 min) after treatment. Results are the mean ± 1 S.D. of five replicates.