Table 1.
Baseline functional data for ex vivo isolated hearts
| C57BL/6J | FVB/NJ | DBA/2J | BALB/cJ | C3H/HeJ | 129X1/SvJ | C57BL/10SnJ | 129S1/SvImJ | |
|---|---|---|---|---|---|---|---|---|
| LVEDP, mmHg | 3.6 ± 0.4 | 3.1 ± 0.5 | 4.3 ± 0.5 | 5.5 ± 1.3 | 4.7 ± 1.2 | 4.5 ± 0.2 | 3.7 ± 0.3 | 3.9 ± 0.3 |
| LVESP, mmHg | 126.3 ± 3.3 | 147.7 ± 5.9* | 130.6 ± 7.0 | 132.4 ± 3.8 | 125.6 ± 2.7 | 121.7 ± 3.7 | 125.9 ± 1.8 | 124.1 ± 3.4 |
| LVDP, mmHg | 122.8 ± 3.6 | 144.6 ± 5.9* | 126.3 ± 7.2 | 126.9 ± 4.5 | 120.9 ± 2.3 | 117.2 ± 3.7 | 122.2 ± 1.8 | 120.2 ± 3.5 |
| −dP/dt, mmHg/s | −3456 ± 185 | −4137 ± 148 | −3618 ± 310 | −3929 ± 216 | −3681 ± 223 | −3386 ± 267 | −3781 ± 157 | −3184 ± 157 |
| +dP/dt, mmHg/s | 4614 ± 396 | 4697 ± 200 | 4429 ± 445 | 4708 ± 284 | 4338 ± 291 | 4263 ± 345 | 4321 ± 147 | 3654 ± 162 |
| Tau, ms | 22.0 ± 2.0 | 24.1 ± 0.7 | 24.4 ± 1.1 | 21.9 ± 1.6 | 22.5 ± 2.0 | 24.2 ± 1.5 | 22.6 ± 0.5 | 25.9 ± 0.6 |
Baseline functional data for isolated hearts of inbred mouse strains. Systolic function indicated by left ventricular end-systolic pressure (LVESP), left ventricular developed pressure (LVDP), and the maximum derivative of left ventricular pressure (+dP/dt). Diastolic function indicated by left ventricular end-diastolic pressure (LVEDP), minimum derivative of left ventricular pressure (−dP/dt), and the rate constant tau. All values expressed as means ± SE.
*
P < 0.05 compared with C57BL/6J mice; n = 5–8 for each group.