Skip to main content
. Author manuscript; available in PMC: 2010 Oct 20.
Published in final edited form as: Org Biomol Chem. 2009;7(15):3009–3019. doi: 10.1039/B907743J

Table 9.

Palladium-catalyzed hydroamination/cyclization of alkynes32

Entrya Substrate Product Yield (%) ee (%)
1 graphic file with name nihms-184896-t0083.jpg graphic file with name nihms-184896-t0084.jpg 93 92
2 graphic file with name nihms-184896-t0085.jpg graphic file with name nihms-184896-t0086.jpg 90 88
3 graphic file with name nihms-184896-t0087.jpg graphic file with name nihms-184896-t0088.jpg 92 79
4 graphic file with name nihms-184896-t0089.jpg graphic file with name nihms-184896-t0090.jpg 90 95
a

Conditions: 5 mol % Pd2(dba)3·CHCl3, 10 mol% PhCO2H, 20 mol% ligand in PhH at 100 °C, 48 h.

graphic file with name nihms-184896-t0091.jpg