Fig. 5.

Diagram of relative changes in statistically significant differentially expressed genes in blood of the patient (red) using the Human Wnt Signalling Pathway PCR Arrays (SABioscience). Values of the healthy carrier mother (green) that also show statistically significant alterations are marked with an asterisk. Note significant over-expression of LEF1 and down-regulation of many WNT signalling proteins including the Frizzled receptor and transcriptional target genes in the patient. Standard deviations in the patient and the mother are derived from 4 different experiments each, while the standard deviations in controls are derived from single experiments in six different individuals. The commonly narrow standard deviations in the patient and her mother reflect the high reliability of the measurements, while the quite big standard deviations in the controls indicate a broad biological variability in expression levels for many of the genes in blood.