Table 2.
Candidate genes tested for association with cholinesterase activity.
| Chromosome | Position (NCBI Build 36) | Region size (kb) | Genes in region | No. SNPs genotyped |
|---|---|---|---|---|
| 1p13 | chr1:110032012–110037970 | 6 | GSTM1 | 1 |
| 1q24 | chr1:169317930–169580099 | 26 | FMO1, FMO2, FMO3, FMO4 | 77 |
| 2p22 | chr2:38147818–38157803 | 10 | CYP1B1 | 3 |
| 3p21 | chr3:49686778–49696389 | 10 | APEH | 3 |
| 3q26 | chr3:166973387–167037944 | 65 | BCHE | 13 |
| 7q21 | chr7:94764502–94903130 | 160 | PON1, PON2, PON3 | 57 |
| 7q22 | chr7:99028551–99308888 | 280 | CYP3A4, CYP3A5, CYP3A7, CYP3A43 | 19 |
| 7q22 | chr7:100325448–100332411 | 7 | ACHE | 10 |
| 10q23 | chr10:96392874–96828191 | 436 | CYP2C8, CYP2C9, CYP2C18, CYP2C19 | 49 |
| 10q26 | chr10:135189996–135204549 | 15 | CYP2E1 | 9 |
| 17q13 | chr11:67107761–67110712 | 3 | GSTP1 | 8 |
| 15q24 | chr15:72795630–72838597 | 43 | CYP1A1, CYP1A2 | 11 |
| 16p11 | chr16:28503439–28546981 | 44 | SULT1A1, SULT1A2 | 6 |
| 16q12 | chr16:54392027–54429859 | 38 | CES1 | 4 |
| 16q22 | chr16:65523286–65566894 | 44 | CES2, CES3 | 6 |
| 19q13 | chr19:46174140–46222459 | 50 | CYP2B6 | 11 |
Abbreviations: APEH, N-acylaminoacyl-peptide hydrolase; CES, carboxylesterase; FMO, flavin containing monooxygenase; GSTM, glutathione S-transferase mu; GSTP, glutathione S-transferase pi; NCBI, National Center for Biotechnology Information (http://www.ncbi.nlm.nih.gov/); SULT, sulfotransferase.