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. 2003 Apr;9(4):462–468. doi: 10.3201/eid0904.020395

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This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.

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Phylogenetic relationships of human enterovirus 71 (HEV71) strains belonging to genogroup B (21). Dendrogram shows the genetic relationships among 56 HEV71 strains belonging to genogroup B, based on the alignment of the complete VP4 gene sequence (nucleotide positions 744-950). Details of the HEV71 strains included in the dendrogram are provided in Appendix Tables 1 and 2. Branch lengths are proportional to the number of nucleotide differences. The bootstrap values in 1,000 pseudoreplicates for major lineages within the dendrogram are shown as percentages. The marker denotes a measurement of relative phylogenetic distance. The VP4 nucleotide sequence of coxsackie virus A16 (CA16) (29) was used as an outgroup in the analysis. *Denotes HEV71 isolates from fatal cases; †Denotes HEV71 strains falling outside existing genogroup boundaries.