Skip to main content
. Author manuscript; available in PMC: 2010 Oct 20.
Published in final edited form as: Nat Genet. 2009 Nov 1;41(12):1350–1353. doi: 10.1038/ng.471

Figure 2.

Figure 2

DNA methylation at R-DMRs distinguishes normal tissues from each other and colon cancer from normal colon. (a,b) The M values of all tissues from the 4,401 regions (FDR < 0.05) corresponding to R-DMRs (iPS cells compared to parental fibroblasts) were used for unsupervised hierarchical clustering comparing (a) normal brain, spleen and liver (denoted as Br, Sp and Lv, respectively) and (b) colorectal cancer and matched normal colonic mucosa (denoted as T and N, respectively). Notably, all of the normal brain, spleen and liver tissues are completely discriminated by the regions that differ between iPS cells and fibroblasts (R-DMRs). The major branches in the dendrograms correspond perfectly to tissue type. Furthermore, most of the colorectal cancer samples are discriminated from matched normal colonic mucosa by R-DMRs.