Table 4.

Brain Krebs Cycle and Coenzyme A (CoA) Intermediates

	Saline	Ethanol	Acetate
Citrate	0.286 ± 0.034	0.268 ± 0.023b	0.373 ± 0.047
Isocitrate	0.022 ± 0.0005	0.023 ± 0.001	0.022 ± 0.0002
α-Ketoglutarate	0.170 ± 0.004	0.170 ± 0.005	0.201 ± 0.007a,b
Succinyl CoA (μM)	3.36 ± 0.47	4.15 ± 0.41	3.54 ± 0.24
Succinate	0.160 ± 0.007	0.145 ± 0.010	0.158 ± 0.008
Fumarate	0.128 ± 0.010	0.133 ± 0.010	0.169 ± 0.013a
l-Malate	0.266 ± 0.015	0.252 ± 0.024	0.275 ± 0.034
Calc oxaloacetate	0.0068 ± 0.0002	0.0063 ± 0.0005	0.0089 ± 0.0008a,b
Acetyl CoA (μM)	3.40 ± 1.32	3.35 ± 0.31	2.78 ± 0.21
Malonyl CoA (μM)	2.05 ± 0.33	3.15 ± 0.31a	2.32 ± 0.15

Animals infused with solutions of phosphate buffered saline (PBS) (n = 5), 4 M ethanol in PBS (n = 8), or 2 M sodium acetate in PBS (n = 6). Values are means in μmole/g wet weight ± SEM. CoA’s are given in nmol/g wet weight.

^ap < 0.05 between infused and saline group.

^bp < 0.05 between ethanol-infused and acetate-infused, paired t-test with Bonferroni adjustment for multiple group comparisons.