. Author manuscript; available in PMC: 2010 Oct 20.

Published in final edited form as: J Hepatol. 2010 May 6;53(2):298–306. doi: 10.1016/j.jhep.2010.03.011

Table 1.

Levels of TNFα, endocannabinoids, nitrites/nitrates (NOx), total glutathione, oxidized glutathione, and reduced glutathione.

Test	BDL-V	BDL-anti-TNFα	BDL-anti-TNFα−/−	Sham-V	Sham-anti-TNFα	Sham-TNFα−/−
Plasma TNFα level (pg/ml)	244.19 ± 21.93^*	132.23 ± 19.73^†	–	85.88 ± 9.74	82.98 ± 8.51	81.76 ± 11.21
Cardiac anandamide (fmol/mg)	14.5 ± 3.6^*	7.9 ± 2.9^†	6.4 ± 3.1^†	5.9 ± 1.9	–	–
Cardiac 2-arachidonoylglycerol (fmol/mg)	0.8 ± 0.09	1.1 ± 0.02	1.2 ± 0.07	0.7 ± 0.04	–	–
Cardiac NOx (µmol/mg)	5.71 ± 0.47^*	4.44 ± 0.54^†	4.08 ± 0.67^†	3.65 ± 0.49	3.70 ± 0.84	3.91 ± 0.99
Cardiac total glutathione (tGSH, µg/mg)	7.25 ± 0.91^*	9.83 ± 0.83^†	10.25 ± 1.04^†	12.73 ± 1.26	11.6 ± 1.03	10.9 ± 2.15
Cardiac oxidized glutathione (GSSG, µg/mg)	0.68 ± 0.09	0.84 ± 0.02	0.85 ± 0.05	0.90 ± 0.08	0.84 ± 0.06	0.96 ± 0.09
Ratio of cardiac tGSH/GSSG (%)	9.37	8.54	8.29	7.06	7.27	6.99
Reduced cardiac glutathione (rGSH, µg/mg)	6.56 ± 1.12^*	8.99 ± 1.25^†	9.41 ± 1.09^†	11.83 ± 1.19	10.75 ± 1.36	12.05 ± 2.1

BDL/sham-V: BDL or sham mice receiving vehicle treatment. BDL-anti-TNFα/sham-anti-TNFα: BDL or sham mice receiving chronic anti-TNFα antibody treatment. BDL-TNFα−/−: TNFα knockout BDL mice.

p <0.05 vs. sham-V.

^†

p <0.05 vs. BDL-V.