Figure 5.
(A) Thrombopoietin dose–response studies in vivo. Percent infarction in the left ventricle following a 15 min treatment with thrombopoietin (0.005, 0.05, or 0.5 μg/kg iv) prior to 30 min of regional ischaemia and 180 min of reperfusion. (B) Phase of action of thrombopoietin. Infarct size was determined after 30 min regional ischaemia and 120 min reperfusion. Data are mean ± SD, n = 6 hearts per group. *P < 0.05, thrombopoietin vs. drug-free control.