Table 1.
Baseline characteristics of prostate cancer cases and controls
| Cases (N=564) |
Controls (N=758) |
|
|---|---|---|
|
| ||
| Mean age at baseline (±SD) | 61.2 (±7.7) | 61.2 (±7.6) |
| Mean age at diagnosis (±SD) | 68.5 (±6.7) | - |
| Mean BMI (±SD) | 24.7 (±2.4) | 24.5 (±2.5) |
| Smoking status (%) | ||
| Current | 257 (45.6) | 345 (45.5) |
| Former | 259 (45.9) | 346 (45.7) |
| Never | 48 (8.5) | 67 (8.8) |
| BMI | ||
| <25 | 327 (58.0) | 477 (62.9) |
| 25 - <30 | 220 (39.0) | 262 (34.6) |
| 30+ | 17 (3.0) | 19 (2.5) |
| Race | ||
| Caucasian | 541 (96.6) | 717 (95.4) |
| Non-Caucasian | 19 (3.4) | 35 (4.6) |
| Gleason score (%) | ||
| 2-6 | 304 (60.7) | - |
| 7-10 | 197 (39.3) | - |
| Tumor stage (%) | ||
| A/B (localized) | 343 (66.5) | - |
| C, D or lethal (advanced) | 173 (33.5) | - |
| PSA era (%) | ||
| ≤1991 | 387 (68.6) | - |
| >1992 | 177 (31.4) | - |
| PTEN gene polymorphism (%) | ||
| No insertion | 242 (43.3) | 323 (42.9) |
| Heterozygous | 266 (47.6) | 349 (46.4) |
| Insertion | 51 (9.1) | 81 (10.8) |
| Pi3k gene polymorphism (%) | ||
| GG | 375 (68.6) | 495 (67.4) |
| GA | 161 (29.4) | 225 (30.7) |
| AA | 11 (2.0) | 14 (1.9) |
| IRS-1 gene polymorphism (%) | ||
| GG | 489 (86.7) | 662 (87.3) |
| GA | 73 (12.9) | 90 (11.9) |
| AA | 2 (0.4) | 6 (0.8) |