(A and B) J774-C, J774-H46Q, and J774-GX cells were incubated in the presence or absence of 1 μM T0901317 for 20 h as indicated, prior to RT-PCR. Data are means ± SEM (n = 4) and are representative of 3 experiments; values that are not significantly different (p ≥ 0.05) are indicated with the same letter. (C) J774-C and J774-GX cells were transfected with either a control siRNA (scr), siRNA targeting LXRα, siRNA targeting LXRβ or siRNAs targeting both LXRα and LXRβ for 24 h, and then treated with 1 μM T0901317 for an additional 20 h, prior to RT-PCR. Data are means ± SEM (n = 4) and are representative of 2 experiments; Data that are not significantly different (p ≥ 0.05) are indicated with the same letter.