Table 4.

Heart rate (HR; beats/min) and mean arterial pressure (MAP; mmHg) data during in vivo rat experiments of with BAY 60-6583.

	HR	MAP	HR	MAP	HR	MAP	HR	MAP
	Pre-Drug Baseline		1′ Pre-Ischemia		15′ Ischemia		2h Reperfusion
Vehicle	358 ± 12	117 ± 6	362 ± 13	116 ± 6	372 ± 12	97 ± 7	350 ± 14	80 ± 10*
BAY 0.3 mg/kg	350 ± 15	111 ± 4	367 ± 9	112 ± 4	383 ± 12	95 ± 10	343 ± 9	70 ± 8*
BAY 1.0 mg/kg	384 ± 7	115 ± 7	378 ± 15	111 ± 6	388 ± 9	108 ± 8	352 ± 8	80 ± 7*
BAY 1 mg/kg +ATL 1 mg/kg	385 ± 13	110 ± 3	383 ± 8	125 ± 4	365 ± 8	96 ± 7	350 ± 13	74 ± 3*

^*P < 0.5 vs. respective pre-drug baseline value by repeated-measures ANOVA and Dunnett’s t test