TABLE 1.
Clinicopathological features in skin-sparing mastectomies (SSM) with positive (N = 64) and negative (N = 104) superficial specimen margins
| Clinicopathological factors | Positive (N = 64) | Negative (N = 104) | P-value |
|---|---|---|---|
| Mean age (range)a | 50.0 ± 12.4 (32–80) | 52.7 ± 14.6 (26–85) | 0.1226 |
| Mean mastectomy weight (g) (range) | 436 (103–1842) | 510 (148–2318) | 0.018 |
| Mean mastectomy volume (cm3) (range) | 1084 (202–5967) | 1331 (163–4173) | 0.07 |
| Mean skin area (cm2) (range) | 34.4 (4.0– 247.5) | 61.7 (1.4–359.1) | 0.01 |
| Mean skin/mastectomy surface area (cm2) (range) | 0.11 (0.02–0.79) | 0.17 (0.01–0.84) | 0.01 |
| Mean ASM thickness (cm) (range) | 0.93 (0.1–2.5) | 0.77 (0.1–1.6) | 0.03 |
| Mean ASM surface area (cm2) (range) | 9.36 (0.5 –31.76) | 10.82 (0.49–90.0) | 0.3620 |
| Mean ASM volume (cm3) (range) | 10.41 (0.18–61.88) | 9.29 (0.30–98.8) | 0.6042 |
| DCIS only | 13 | 22 | 0.055 |
| IMC ± DCIS | 51 | 82 | |
| Extensive DCIS | 17 | 13 | 0.032 |
| DCIS nuclear grade | |||
| I | 4 | 2 | 0.6172 |
| II | 20 | 24 | |
| III | 31 | 34 | |
| IMC Elston grade | |||
| I | 5 | 6 | 0.6788 |
| II | 21 | 33 | |
| III | 23 | 38 | |
| No grade given | 2 | 5 (too small to grade) | |
| Stage (invasive carcinoma) | |||
| pT1 | 31 | 51 | 0.9710 |
| pT2 | 14 | 22 | |
| pT3 | 5 | 6 | |
| pT4 | 1 | 2 | |
| Not available | 0 | 1 | |
| Mean tumor size (cm) (range) | 2.2 (0.1–11.7) | 2.5 (0.1–15.7) | 0.4965 |
| Carcinoma in > 1 quadrant | 35 | 32 | 0.02 |
| Paget’s disease | 0 | 1 | 1.00 |
| Lymph node metastasis | 23 | 25 | 0.10 |
| Mean number of lymph node metastases | 4.9 (1–25) | 3.6 (1–14) | 0.3616 |
| Extranodal extension | 6/23 | 5/25 | 0.7362 |
| Vascular invasion | 18/51 | 14/82 | 0.025 |
| Estrogen receptor positive | 52 of 60 | 51 of 81 | 0.01 |
| Progesterone receptor positive | 46 of 60 | 40 of 81 | 0.01 |
| Her-2/neu status (IHC score) | |||
| 0–1 | 25/46 | 44/62 | 0.002 |
| 2–3 | 21/46 | 18/62 | |
| Positive deep margin | 24 | 6 | < 0.001 |
| Prior neoadjuvant chemotherapy | 10 | 28 | 0.04 |
a
The number of patients in the former group was 61 (three patients had bilateral mastectomies: two patients had bilateral positive superficial margins and one patient had one positive and one negative superficial margin). Accordingly the number of patients in the latter group was 102.
ASM, additional superficial margin; DCIS, ductal carcinoma in situ; IMC: invasive mammary carcinoma, ductal or lobular; IHC, immunohistochemical stain.
Bold values indicates statistically significant differences.