Table 2. Validation of changes in expression levels of genes encoding heat shock proteins carbohydrate metabolism, developmental process and lipid metabolism in dmDys exposed to hypobaric and normobaric CH.

Category	Gene	CH-dmDys-Hypobaric	CH-dmDys-Normobaric
Response to stress	Hsp 23	−7.34±0.04*	−1.23±0.16
	Hsp 26	−7.74±0.023**	−2.45±0.28*
	Hsp 27	−6.24±0.05***	−2.66±0.11***
	Hsp67	−624.26±0.01***	−19.55±0.02**
	Hsp67BC	−64.84±0.01 ***	−14.41±0.01***
	Hsp68	−89.08±0.03***	−6.99±0.05*
Carbohydrate Metabolism	Hexokinase C	4.64±1.12*	4.74±0.70***
	Mannosidase 1	3.84±1.01*	4.16±1.45*
	CG5288	5.42±1.48*	2.25±0.53 **
	CG17026-PA	6.16±2.56 *	6.00±2.28*
Developmental process	Odorant binding protein 99B	8.57±3.24 **	1.84±0.63*
Lipid metabolism	Juvenile hormone esterase	1.37±0.31	1.18±0.41

Concordant decreases in levels of genes encoding HSP expression and increases in genes encoding carbohydrate metabolism, developmental process and lipid metabolism were noted in dmDys exposed to both hypobaric or normobaric hypoxia compared to normoxic dmDys. Values are mean ± SD.

*p<0.05.

**p<0.01;

***p<0.001 vs. normoxic dmDys.