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Concentration of DOX in the tumour tissue compartment for the administration of free-DOX and LTSL-DOX versus the radius (see Figure 6 for location), 30 min after start of ablation (A). DOX concentration for LTSL-DOX varies along the radius, whereas for free-DOX there is little variation. The maximum concentration of DOX in the LTSL-DOX case was reached just outside of the ablation zone in a region of considerably reduced perfusion (B).
