Table III.

Model parameters.

Symbol	Description	Value	Source
BW	Body weight	70 kg	assumed
D	Total dose of encapsulated DOX injected	49 mg	assumed
Hct	Haematocrit	0.45	[34]
Hcttumour	Haematocrit for tumour microvasculature	0.19	[35]
kp	Transfer constant from systemic plasma to tissue	1.6e-3 s−1	calculated with parameters from [36]
ke	Transfer constant for clearance	1.1e-3 s−1	calculated with parameters from [36]
kt	Transfer constant from tissue to systemic plasma	4.6809e-5 s−1	calculated with parameters from [36]
ke_LTSL	Rate constant of LTSL clearance	2.228e-4 s−1	fit to data from [37]
k1ci	Parameter for intracellular uptake	2.2572	[17]
k2ci	Parameter for intracellular uptake	0.0452 kg/m3	[17]
k3ci	Parameter for intracellular uptake	2.8056e-4 s−1	[17]
Kici	Parameter for intracellular uptake	5.2875e-4 kg/m3	[17]
PS	Permeability surface area product for DOX	7e-3 s−1	[14]
UDOX	Factor for binding of DOX to proteins	0.3	[38, 39]
$V_B^B$	Total blood volume in body	5.53 L	calculated with: blood = 7.9% of body weight [2]
$V_p^B$	Volume of systemic plasma	3.04 L	$V_B^B$ (1-Hct)
Vtissue	Volume for body tissue (organs, etc.)	64.47 L	calculated with: blood = 7.9% of body weight [2]
${\upsilon }_{\upsilon }^T$	Volume fraction of tumour vascular space	0.092	[40]
${\upsilon }_p^T$	Volume fraction of tumour plasma space	0.07452	${\upsilon }_{\upsilon }^T$ (1-Hcttumour)
${\upsilon }_e^T$	Volume fraction of tumour EES	0.454	[41]
${\upsilon }_i^T$	Volume fraction of tumour intracellular space	0.454	( $1­{\upsilon }_{\upsilon }^T­{\upsilon }_e^T$)
RR	Release rate of DOX from LTSL	Variable [s−1]	calculated
RR37	Release rate of DOX from LTSL at 37°C	Variable [s−1]	calculated
RR	Release fraction of DOX from LTSL	Variable	bi-exponential fit
$F_{p\upsilon }^T$	Plasma flow in tumour plasma space; note: Fpv=plasma flow/plasma volume	Variable [s−1]	calculated
T	Temperature	Variable [°C]	imported from a prior modeling study [23]
tres	Residence time	Variable [s]	$1/F_{p\upsilon }^T$
Diff	Diffusion coefficient for ablated tissue	1.1e-7 cm2/s	[16]
	Diffusion coefficient for non-ablated tissue	6.7e-7 cm2/s