Figure 1.

Adherence according to frequency of dosing. When findings were compared directly, researchers determined that differences of adherence between QD and BID or BID and QID were not statistically significant. However, the differences between QD and TID, QD and QID, and QID and BID were significant (P=.008, P<.001, and P=.001, respectively)⁸

Source: Claxton AJ, Cramer J, Pierce C. A systematic review of the associations between dose regimens and medication compliance. Clin Ther. 2001;23(8):1296–1310.